In the era of large-scale artificial intelligence, Large Language Models (LLMs) have made significant strides in natural language processing. However, they often lack transparency and generate unreliable outputs, raising concerns about their interpretability. To address this, the Chain of Thought (CoT) prompting method structures reasoning into step-by-step deductions. Yet, not all reasoning chains are valid, and errors can lead to unreliable conclusions. We propose ECCoT, an End-to-End Cognitive Chain of Thought Validation Framework, to evaluate and refine reasoning chains in LLMs. ECCoT integrates the Markov Random Field-Embedded Topic Model (MRF-ETM) for topic-aware CoT generation and Causal Sentence-BERT (CSBert) for causal reasoning alignment. By filtering ineffective chains using structured ordering statistics, ECCoT improves interpretability, reduces biases, and enhances the trustworthiness of LLM-based decision-making. Key contributions include the introduction of ECCoT, MRF-ETM for topic-driven CoT generation, and CSBert for causal reasoning enhancement.